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Home » Plastic Surgeon » Surgeon's Publications

Surgeon's Publications

Dr Lim has published many papers in International Peer Reviewed Plastic Surgery and Research journals since 1992, and still serves as a peer reviewer for journals as well as for competitive grants. He has additionally edited a book on Hand Surgery, and written book chapters on Plastic Surgery, Hand Surgery, and on Stem Cell biology

PUBLICATIONS:

JOURNALS
  1. Lim IJ, Chia YW, Theobald D, Goh P (1993) Laparoscopic exploration of the common bile duct through a choledochotomy: Report of three cases. J Hep Bil Pancr Surg 1: 33-35, 1993

  2. Chua S, Arulkumaran S, Lim IJ, Selamat N, Ratnam SS (1994) Influence of breastfeeding and nipple stimulation on postpartum uterine activity. Br J Obstet Gynaecol 101(9): 804-805, 1994

  3. Lim IJ, Singh K, Prasad RN, Chan HL, Lam RS, Ratnam SS (1994) "Pregnancy tumour" of the nasal septum. Aust NZ J Obstet Gynaecol 34(1): 109-110, 1994

  4. Lim IJ, R Pho, EPC Tock. Atypical extraungual manifestation of a subungual glomus tumour
    Br J Plast Surg 52(4): 327-328, 1999

  5. Chan KO, Lim IJ, Baladas HG, Tan WTL. Multifocal trichilemmal carcinoma: a case report
    Br J Plast Surg 52(8): 665- 667, 1999 (Corresponding Author)

  6. Lim IJ, Phan TT, Song C, Tan WTL, Longaker MT. Investigation of the influence of keloid-derived keratinocytes on fibroblast growth and proliferation in-vitro. Plast Reconstr Surg 107: 797-808, 2001

  7. Peled Z, Lim IJ, Phan TT, Cowan CM, Warren SM, Bouletreau PJ, Crisera FE, Erfani S, Chang J, Longaker MT. Enhanced transforming growth factor-beta (TGF-β1) and reduced Smad 7 gene expression characterize keloid human keratinocytes: implications for keloid pathogenesis. Surg Forum, Vol LII, 563-567, 2001

  8. Lim IJ, Phan TT, Bay BH, Peled Z, Qi R, Pereira BP, Huynh H, Tan WTL, Lee ST, Longaker MT. Induction of keloid-like collagen secretory characteristics in normal fibroblasts co-cultured with keloid-derived keratinocytes. Surg Forum, Vol LII, 560-563, 2001

  9. Phan TT, Lim IJ, Bay BH, Qi R, Pereira BP, Huynh H, Tan WTL, Lee ST, Longaker MT. Differences in collagen production between normal and keloid-derived fibroblasts in serum-media co-culture with keloid-derived keratinocytes. J Dermatol Sci 29(1): 26-34, 2002 (Joint First Authorship)

  10. Lim IJ, Phan TT, Bay BH, Qi R, Huynh H, Tan WTL, Lee ST, Longaker MT. Fibroblasts cocultured with keloid keratinocytes: normal fibroblasts secrete collagen in a keloidlike manner Am J Physiol- Cell Physiol 283: C212-C222, 2002

  11. Lim IJ, Phan TT, Bay BH, Qi R, Longaker MT, Lee ST, Huynh HT. Insulin-like Growth Factor Binding-Protein-3 (IGFBP-3) influences fibroblast proliferation by keloid-derived keratinocytes in-vitro. J Am Coll Surg 195(3S): S49, 2002

  12. Wang Z, Trinidade M, Fong K, Peled Z, Phan TT, Lim IJ, Yang G, Smith L, Longaker MT. Growth factor production by keloid and normal fibroblasts after physical stress J Am Coll Surg 195(3S): S49, 2002

  13. Phan TT, Lim IJ, Bay BH, Qi R, Longaker MT, Lee ST, Huynh H. Role of IGF system of mitogens in the induction of fibroblast proliferation by keloid-derived keratinocytes in vitro Am J Physiol Cell Physiol 284(4):C860-C869, 2003

  14. Chaw CS, Yang YY, Lim IJ, Phan TT, Chung N. Water-soluble betamethasone-loaded poly(lactide-co-glycolide) microparticles as sustained release dosage forms. Effects of formulation, process types and fabrication conditions on the performance of microparticles. J Microencapsulation 20(3): 349-359, 2003


  15. Lim IJ, Phan TT, Bay BH, Qi R, Lee ST, Longaker MT, Huynh HT. Synchronous MAP kinase and PI-3 kinase pathway activation is required for collagen and extracellular matrix production in keloids. Wound Rep Regen. 11(5):A29, 2003

  16. Lim IJ, Phan TT, Tan EK, Nguyen TTT, Tran E, Longaker MT, Song C, Lee ST, Huynh HT. Synchronous activation of ER kinase and PI-3 kinase pathways is required for collagen and extracellular matrix production in keloids. J Biol Chem 278(42): 40851-8, 2003

  17. Phan TT, Lim IJ, Sun L, Chan SY, Bay BH, Tan EK, Lee ST. Quercetin inhibits fibronectin production keloid-derived fibroblasts: implications for the treatment of excessive scars. J Dermatol Science, 2003 (Joint First Authorship)

  18. Yang GP, Lim IJ, Phan TT, Lorenz HP, Longaker MT. From scarless fetal wounds to keloids: molecular studies in wound healing. Wound Rep Regen 11:411-418, 2003

  19. Lim IJ. A New Era of Clinician Scientists Ann Acad Med Singapore 33(1): 117, 2004

  20. Xia W, Phan TT, Lim IJ, Longaker MT, Yang GP. Complex epithelial-mesenchymal interactions modulate transforming growth factor-beta expression in keloid-derived cells. Wound Rep Regen 12: 546-556, 2004

  21. Xia W, Kong W, Phan TT, Lim IJ, Longaker MT, Yang GP. Increased CCN2 transcription in keloid fibroblasts requires cooperativity between AP-1 and Smad binding sites. Annals of Surgery 246(5):886-89, 2007
  22. Phan TT, Lim IJ, Tan EK, Lee ST. Suppression of TGF-beta/smad signaling in keloid-derived fibroblasts by quercetin: Implication for treatment of excessive scars. Journal of Trauma 57: 1032-1037, 2004

  23. Phan TT, Lim IJ, BH Bay, J Tan, ST Lee. Evaluation of cell culture on polyurethane-based membrane - Implication for tissue engineering of skin and other surface tissues. Cell and Tissue Banking 6: 91-97, 2005

  24. Chong EJ, Lim CT, Lim IJ, Phan TT. Application of biotechnology, nanotechnology and tissue engineering in cosmetic medicine. Kosmetische Medizin 5+6: 212-216, 2005 (invited review paper)

  25. Mukhkopadhyay A, Tan EK, Khoo YT, Chan SY, Lim IJ, Phan TT. Epithelial-mesenchymal interactions in keloids induce contraction of fibroblast-populated collagen lattices. British Journal of Dermatology 152: 639-645, 2005

  26. Phan TT, Lim IJ, Aalami O, Loget F, Mukhkopadhyay A, Tan EK, Khoo YT, Longaker MT. Smad3 plays an important role in keloid pathogenesis via epithelial-mesenchymal interactions. Journal of Pathology 207(2): 232-242, 2005

  27. SJ Sebastin, ME Puhaindran, Lim AYT, Lim IJ, Bee WH. The prevalence of absence of the palmaris longus - a study in a Chinese population and a review of the literature. Journal of Hand Surgery (British and European Volume) 30B: 5: 525-527, 2005

  28. Wang Z, Fong KD, Phan TT, Lim IJ, Longaker MT, Yang GP. Increased transcriptional response to mechanical strain in keloids fibroblasts due to increased focal adhesion complex formation. Journal of Cellular Physiology 206(2): 510-507, 2006

  29. Wang LS, Chow PY, Phan TT, Lim IJ, Yang YY. Fabrication and characterization of nano-structured and thermo-sensitive membranes for wound healing and cell grafting. Advanced Functional Materials 16:1171-1178, 2006

  30. Lim CP, Phan TT, Lim IJ, Cao XM. Stat3 contributes to keloid pathogenesis and is a potential therapeutic target for keloid scar formation.  Oncogene 25(39):5416-5425, 2006

  31. Khoo A, Ong CT, Mukhopadhyay A, Han HC, Do DV, Lim IJ, Phan TT. Up-regulation of secretory Connective Tissue Growth Factor (CTGF) in keratinocyte-fibroblast coculture contributes to keloid pathogenesis. Journal of Cellular Physiology 208(2): 336-343, 2006

  32. Xia W, Phan TT, Lim IJ, Longaker MT, Yang GP. Differential transcriptional responses of keloid and normal keratinocytes to serum stimulation. Journal of Surgical Research 135(1): 156-163, 2006

  33. Wang LS, Chow PY, Phan TT, Lim IJ and Yang YY. "Fabrication and Characterization of Nanostructured and Thermosensitive Polymer Membranes for Wound Healing and Cell Grafting". Advanced Functional Materials 16:1171-1178, 2006
  34. Ong CT, Khoo YT, Mukhkopadhyay A, Khoo YT, Do DV, Han HC, Lim IJ, Phan TT. Epithelial-mesenchymal interactions in keloid pathogenesis modulate vascular endothelial growth factor expression and secretion. Journal of Pathology 211(1): 95-108, 2007

  35. Mukhkopadhyay A, Khoo YT, Chan SY, Philips D, Lim IJ, Phan TT. The role of activin system in keloid pathogenesis. American Journal of Physiology- Cell Physiology 292(4): C1331-8, 2007

  36. Do DV, Lim IJ, Phan TT. Roles of epithelial-mesenchymal interactions in keloid scar pathogenesis and carcinogenesis. A review. Current Signal Transduction Therapy 2(3): 214-220, 2007 (invited review paper)

  37. Ong CT, Khoo YT, Mukhopadhyay A, Do DV, Lim IJ, Aalami O, Phan TT. mTOR as a potential therapeutic target for treatment of keloids and excessive scars. Experimental Dermatology 16: 394-404, 2007

  38. Chong EJ, Lim CT, Phan TT, Lim IJ, Zhang YZ, Bay BH, Ramakrisnan S. Evaluation of electrospun PCL/gelatin nanofibrous scaffold for wound healing and layered dermal reconstitution. Acta Biomaterialia 3(3):321-330, 2007

  39. Mukhopadhyay A, Khoo YT, Chan SY, Lim IJ, Aalami O, Phan TT. Targeting of Sp1 Transcription Factor: A Novel Therapeutic Approach for Keloids, an in vitro analysis. Experimental Dermatology 16(12): 1023-1031 5, 2007

  40. Xia W, Kong W, Phan TT, Lim IJ, Longaker MT, Yang GP. Increased CCN2 transcription in keloid fibroblasts requires cooperativity between AP-1 and Smad binding sites. Annals of Surgery 246(5):886-89, 2007

  41. Ong CT, Khoo YT, Mukhkopadhyay A, Khoo YT, Do DV, Han HC, Lim IJ, Phan TT*. Epithelial-mesenchymal interactions in keloid pathogenesis modulate vascular endothelial growth factor expression and secretion. Journal of Pathology 211(1):95-108, 2007

  42. Lee SJ, Lim AY, Lim IJ, Lim TC, Pho RW. Innervation of the Face Studied Using Modifications to Sihler's Technique in a Primate Model. Plast Reconstr Surg 121(4):1188-205, 2008 Apr

  43. Ruetze M, Gallinat S, Lim IJ, Chow E, Phan TT, Staeb F, Wenck H, Deppert W, Knott. Common features of umbilical cord epithelial cells and epidermal keratinocytes. Journal of Dermatological Science 50:227-231, 2008
  44. Lim CP1, Phan TT, Lim IJ, Cao XM. Cytokine profiling and Stat3 phosphorylation in epithelial-mesenchymal interactions between keloid keratinocytes and fibroblasts. Journal of Investigative Dermatology 129(4):851-861, 2009

  45. Mukhopadhyay A, Chan SY, Khoo A, Ong CT, Lim IJ, Phan TT. Syndecan-2 and decorin: proteogylcanswith a difference- implications in keloid pathogenesis. The proteoglycans of difference. Journal of Trauma 68(4): 999-1008, 2010

  46. Mukhopadhyay A, Chan SY, Do DV, Khoo A, Ong CT, Lim IJ, Phan TT. The role of Stem Cell Factor/c-Kit in keloid pathogenesis.Do tyrosine kinase inhibitors have a potential therapeutic role? British Journal of Dermatology 2011 Feb;164(2):372-86

  47. Ooi B, Do DV, Khoo A, Ong CT, Lim IJ, Phan TT. Hepatoma-derived growth factor and its role in keloid pathogenesis. Journal of Cellular and Molecular Medicine 14(6A):1328-37, 2010 Jun

  48. Ong CT, Khoo YT, Mukhopadhyay A, Masilamani J, Do DV, Lim IJ, Phan TT. Comparative proteomic analysis between normal skin and keloid scar. British Journal of Dermatology 2010 Jun;162(6):1302-15

  49. Mukhopadhyay A, Chan SY, Do DV, Khoo A, Ong CT, Lim IJ, Phan TT. The role of Hepatocyte Growth Factor/c-Met system in keloid pathogenesis. Journal of Trauma 2010 Dec;69(6):1457-66

  50. Do DV, Ong CT, Khoo YT, Carbone A, Lim CP, Wang S, Mukhopadhyay A, Cao XM, Cho DH, Wei XQ, Bellone G, Lim IJ, Phan TT. Interleukin-18 system plays and important role in keloid pathogenesis via epithelial-mesenchymal interactions. British Journal of Dermatology 2012 Jun; 166(6):1275-88

  51. Lim IJ, Phan TT. Epithelial and Mesenchymal Stem Cells From the Umbilical Cord Lining Membrane. Cell Transplantation 2014, 23: 497-503

BOOK CHAPTERS
  1. Lim IJ, Kour AK, Pho RWH. Lengthening in free vascularised fibular graft
    Hand Clinics 15(4): 585- 588, 1999

  2. Lim IJ, Lim BH. Nerve Compression Injuries in General Practitioners' Guide to Hand Surgery, Lim BH, Looi KP, Lim IJ (Eds), 2000

  3. Do DV, Masilamani J, Lim IJ, Phan TT. Chapter 26: Derivation of Hepatocytes from Human Umbilical Cord Lining Epithelial Cells. In: Bongso A, Lee EH (Eds). Stem Cells: From Bench to Bedside 2nd Edition, World Scientific Publishing Group, 2010
PATENTS AND INTELLECTUAL PROPERTY
  1. Lim CP, Phan TT, Lim IJ, Cao XM. Use of compositions that modulate STAT genes in the manufacture of medicaments for treating and preventing fibroproliferative disease. Patent filling number IMC/P/2666/PCT

  2. Chong EJ, Lim CT, Phan TT, Ramakrishna S, Lim IJ. A composite, method of producing the composite and uses of the same. Patent filing date 23 September 2004, US Provisional Patent Application No. 60/614,431, US Patent and Trade Mark Office

  3. Phan TT, Lim IJ. Isolation and cultivation of epithelial and mesenchymal stem/progenitor cells. Patent filing date 16 August 2004. US Provisional Patent Application No. 60/602,208, US Patent and Trade Mark Office.

  4. Phan TT, Lim IJ. Isolation, cultivation and uses of stem/progenitor cells. Patent filing date 01 December 2004. US Provisional Patent Application No. 60/632,209, US Patent and Trade Mark Office.

  5. Phan TT, Lim IJ. Isolation, cultivation and uses of stem/progenitor cells. Patent filing date 19 August 2005. PCT Application No. PCT/SG2005/000174.

  6. Yang YY, Phan TT, Lim IJ. Application of drug-loaded nanoparticles for treatment of skin wound healing and pathological scars. Patent filing in progress

  7. Chong EJ, Lim CT, Ramakrishna S, Lim IJ, Phan TT. A composition method of producing the composite and uses of the same. CHONG EJ 01-PCT/JP; Publication No: 2008-514341; Publication Date 8 May 2008.

  8. Chong EJ, Lim CT, Phan TT, Ramakrishna S, Lim IJ. A composition method of producing the composite and uses of the same. Granted patent by Patent Office of Japan. Patent number:

  9. Chong EJ, Lim CT, Phan TT, Ramakrishna S, Lim IJ. A composition method of producing the composite and uses of the same. Granted Patent by the Republic of Singapore. Patent number:

  10. Phan TT, Lim IJ. Isolation and cultivation of stem/progenitor cells from the amniotic membrane of umbilical cord and uses of cells differentiated therefrom. US Patent Application filing date 21 October 2005. No 60/729,172

  11. Phan TT, Lim IJ. Isolation of stem/progenitor cells from amniotic membrane of umbilical cord. Granted patent by the UK Intellectual Property Office. Patent number: GB2432166

  12. Phan TT, Lim IJ. Isolation of stem/progenitor cells from amniotic membrane of umbilical cord. Granted patent by the Hong Kong Intellectual Property Office. Patent number: HK1104061

  13. Phan TT, Lim IJ. Isolation of stem/progenitor cells from amniotic membrane of umbilical cord. Granted patent by the Vietnam Intellectual Property Office. Patent number: 1-2007-00574

  14. Phan TT, Lim IJ. Isolation of stem/progenitor cells from amniotic membrane of umbilical cord. Granted patent by the Republic of South Africa Patent Office. Patent number: 2007/2144

  15. Phan TT, Lim IJ. Isolation of stem/progenitor cells from amniotic membrane of umbilical cord. Granted patent by the Republic of Singapore Patent Office. Patent number: 129482

  16. Phan TT, Lim IJ. Isolation of stem/progenitor cells from amniotic membrane of umbilical cord. Granted patent by the Taiwan Patent Office. Patent number: 312009

  17. Phan TT, Lim IJ. Isolation of stem/progenitor cells from amniotic membrane of umbilical cord. Granted patent by the Republic of Indonesia Patent Office. Patent number: ID P0023508

  18. Phan TT, Lim IJ. Isolation of stem/progenitor cells from amniotic membrane of umbilical cord. Granted patent by the Patent Office of the United Mexican States. Patent number: 282372

  19. Phan TT, Lim IJ. Isolation of stem/progenitor cells from amniotic membrane of umbilical cord. Granted patent by the Patent Office of the Russian Federation. Patent number: 2416638

  20. Phan TT, Lim IJ. Isolation of stem/progenitor cells from amniotic membrane of umbilical cord. Granted patent by the Patent Office of Israel. Patent number: 181340

  21. Phan TT, Lim IJ. Isolation of stem/progenitor cells from amniotic membrane of umbilical cord. Granted patent by the Patent Office of Australia. Patent number: 2005273077

  22. Phan TT, Lim IJ. Isolation of stem/progenitor cells from amniotic membrane of umbilical cord. Granted patent by the Patent Office of New Zealand. Patent number: 553695

  23. Phan TT, Lim IJ. Isolation of stem/progenitor cells from amniotic membrane of umbilical cord. Granted patent by the Patent Office of Malaysia. Patent number: MY-141772-A

  24. Phan TT, Lim IJ. Isolation of stem/progenitor cells from amniotic membrane of umbilical cord. Granted patent by the Patent Office of China. Patent number: 200580034996.7

  25. Phan TT, Lim IJ. Isolation of stem/progenitor cells from amniotic membrane of umbilical cord. Granted patent by the Patent Office of South Korea. Patent number: 10-2007-7005989

  26. Phan TT, Lim IJ. Isolation of stem/progenitor cells from amniotic membrane of umbilical cord. Granted patent by the Patent Office of India. Patent number: 258562

  27. Phan TT, Lim IJ. Isolation of stem/progenitor cells from amniotic membrane of umbilical cord. Granted patent by the Patent Office of European Community. Patent number: 5743325.2

  28. Phan TT, Lim IJ. Isolation of stem/progenitor cells from amniotic membrane of umbilical cord. Granted patent by the Patent Office of USA. Patent number: 11/205.248
 
 
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